Alteraciones psicosociales y dimensiones de la calidad de vida en pacientes con daño cerebral adquirido

RESUMEN El objetivo del estudio estuvo dirigido a establecer los indicadores de alteraciones psicosociales y las dimensiones que interfieren en la calidad de vida, según el paciente con daño cerebral adquirido, sus familiares y los especialistas de asistencia, pertenecientes al Consejo Popular San Juan de Dios. Se realizó un estudio mixto cuanticualitativo en el período comprendido entre mayo de 2018 y mayo de 2020, el que se extiende hasta hoy, atendiendo a los resultados que se han incorporado a la práctica médica sobre la base de la implementación de un proyecto de investigación que se ejecutó a partir de la colaboración entre el Centro de Desarrollo de las Ciencias Sociales y Humanísticas en Salud y el Hospital Universitario Manuel Ascunce Domenech, de Camagüey. La muestra la constituyeron 30 pacientes y sus familiares, pertenecientes a los consultorios de mayor prevalencia en los casos objeto de estudio. Para el desarrollo de la investigación se emplearon métodos empíricos, teóricos y matemático-estadísticos y se aplicó la escala de la calidad de vida del paciente con daño cerebral (CAVIDACE), dirigida a la familia. Como principales resultados se determinó que las principales funciones psíquicas superiores que mostraron alteraciones fueron los procesos de atención y memoria. Se apreciaron en la mayoría de los pacientes alteraciones emocionales, conductuales, en la autonomía funcional y en la integración social. Las dimensiones de la calidad de vida que evidencian más alteraciones fueron la inserción social, el bienestar emocional y físico, el desarrollo personal y las relaciones interpersonales. De acuerdo con el percentil de la escala se evidenciaron resultados de calidad de vida baja en la mayoría de los pacientes, posterior al daño cerebral adquirido.

ABSTRACT The general objective of the study was aimed at establishing the indicators of psychosocial alterations and the dimensions that interfere with quality of life, according to the patient with acquired brain injury, their relatives and assistance specialists, belonging to the San Juan de Dios Popular Council. A mixed quantitative-qualitative study was carried out in the period between May 2018 and May 2020, which extends until today, based on the results that have been incorporated into medical practice based on the implementation of a research project that It was executed from the collaboration between the Center for the Development of Social and Humanistic Sciences in Health and the Manuel Ascunce Domenech University Hospital, in Camagüey. The sample was made up of 30 patients and their relatives, belonging to the most prevalent clinics in the cases under study. For the development of the research, empirical, theoretical and mathematical-statistical methods were used, and the scale of the quality of life of the patient with brain damage (CAVIDACE), aimed at the family, was applied. As main results, it was determined that the main superior psychic functions that showed alterations were: attention and memory processes. Emotional, behavioral, functional autonomy and social integration alterations were observed in most of the patients. The dimensions of quality of life that showed more alterations were: social insertion, emotional and physical well-being, personal development and interpersonal relationships. According to the percentile of the scale, results of low quality of life were evidenced in most of the patients, after to the acquired cerebral damage.

Fundamentos teóricos para la formación de habilidades del cuidador de pacientes con daño cerebral adquirido

RESUMEN El presente texto hace referencia a la gran carga física y psíquica que contrae el cuidador como consecuencia del cuidado de pacientes con Daño Cerebral Adquirido. Su objetivo está dirigido a sistematizar los elementos epistemológicos acerca de la sobrecarga del cuidador de pacientes con Daño Cerebral Adquirido, en función de mejorar las repercusiones físicas, emocionales, médicas, sociales y económicas que pueden experimentar en su atención. Este artículo constituye una salida del proyecto de investigación Intervención psicosocial para perfeccionar la atención integral al paciente con Daño Cerebral Adquirido, el cual gestiona el Centro para el Desarrollo de las Ciencias Sociales y Humanísticas en Salud, de la Universidad de Ciencias Médicas de Camagüey. El tipo de estudio es Investigación- acción participativa y se ejecutó en el período comprendido entre enero de 2018 y febrero de 2020.

ABSTRACT The present text makes reference to the great load physics and psychic that contracts the caretaker like consequence of the care of patient with Acquired Brain Damage (ABD). Its objective is directed to base the epistemological elements on the caretaker's overload for its attention. It is intruded in inherent questions to the ABD and the physical, emotional repercussions, doctors, social, economic, and others that the caretakers of these patients can experience. This article constitutes an exit of the project of investigation Psychosocial intervention to perfect the integral attention to the patient with Acquired Brain Damage, which negotiates the Center for the Development of the Social and Humanistic Sciences in Health, of the University of Medical Sciences of Camagüey. The study type is of character Investigation-action participatory and it was executed in the period between January of 2018 and February of 2020.

Evidence of Food Safety in Relation to Cry Proteins in Genetically Modified Foods / Evidencias sobre seguridad alimentaria con relación a Cry proteínas en alimentos transgénicos

Abstract Developments in applying biotechnology to crops have generated strong ethical and social debates about its use. This study was aimed at reviewing epidemiological evidence regarding the consumption of genetically modified foods and the possible effects on human health, particularly certain insect-resistant crops in which isolated Bacillum thurigiensis Cry protein has been introduced. An in-depth review of databases was conducted for 2007-2019. Articles not referring to human health were excluded. In total, 1,350 were obtained and 118 were reviewed. As a result, it can be concluded that most studies have focused on chemical composition and in vitro or laboratory animal trials. Furthermore, the guiding principle of substantial equivalency, generally used today to evaluate potential health effects, should not replace rigorously evaluating products with nutritional, immunological, and toxicological trials. Lastly, this review demonstrates a lack of epidemiological evidence, and therefore, the safety of these foods cannot be conclusively determined based on evidence.

Resumen El desarrollo de la biotecnología aplicada a los cultivos ha generado fuertes debates éticos y sociales sobre su uso. El presente estudio tuvo por objetivo revisar las evidencias epidemiológicas existentes relacionando el consumo de alimentos genéticamente modificados, en particular aquellos provenientes de cultivos con resistencia a algunos insectos plagas en los que se han introducido proteínas Cry aisladas de Bacillum thurigiensis con probables daños o trastornos en la salud de las personas. Se realizó una revisión en profundidad en el periodo 2007 a 2019, en bases de datos. Se excluyeron aquellos artículos que no hacían referencia a salud humana. Se obtuvieron 1 350 y finalmente se revisaron 118. La revisión permitió concluir que la mayoría de los estudios existentes se centran en información respecto a la composición química y ensayos in vitro o en laboratorio con animales. Igualmente, que el principio rector de equivalencia sustancial hoy utilizado en forma generalizada para la evaluación de potenciales efectos en salud, no debería sustituir la necesidad de una evaluación rigurosa de los productos incluyendo ensayos nutricionales, inmunológicos y toxicológicos. Por último se comprueba también que la evidencia epidemiológica incluida es insuficiente por lo que lo que no es posible concluir a partir de ella, sobre la inocuidad de estos alimentos.

Miniaturized QuEChERS based methodology for multiresidue determination of pesticides in odonate nymphs as ecosystem biomonitors.

The impacts of the modern, agrochemicals based agriculture that threatens the overall systems sustainability, need to be monitored and evaluated. Seeking for agroecosystems monitors, the present article focus in the occurrence and abundance of aquatic macroinvertebrates, that have been frequently used as bioindicators of water quality due to their relationship with land use. Some of these organisms are on the top of the food chain, where bioaccumulation and biomagnification processes can be observed, and they can turn into secondary pollution sources of systems and terrestrial organisms as well. Odonate nymphs, which belong to the functional group of predators, were selected for this study. A methodology to determine 73 pesticide residues in odonate nymphs by LC-MS/MS and GC-MS/MS was developed. A QuEChERS sample preparation strategy was adapted. As it is complex to obtain samples especially in disturbed ecosystems, the method was minimized to a sample size of 200mg of fresh nymphs. The method was validated and good recoveries (71-120%) with RSDs below 20% for the majority of the studied pesticides at least at two of the assayed levels 1, 10 and 50µgkg-1 were obtained. For 32 analytes the limit of quantitation was 1µgkg-1 and 10µgkg-1 for the others. The lineal range was observed between 1-100µgkg-1 in matrix-matched and solvent calibration curves for most of the assessed pesticides. LC-MS/MS matrix effects were evaluated, 40% of the analytes presented low or no signal suppression. Only flufenoxuron presented high matrix effects. The obtained methodology is adequate for pesticide multiresidue analysis in aquatic macroinvertebrates (odonates) aiming to contribute to the ecological state evaluation of freshwater ecosystems.